Adult Cerebral Malaria: Acute and Subacute Imaging Findings, Long-term Clinical Consequences

Charles Coughlan; Hans Rolf Jäger; David Brealey; Francesco Carletti; Harpreet Hyare; Rajyabardhan Pattnaik; Praveen K Sahu; Sanjib Mohanty; Sarah Logan; Angelika Hoffmann; Samuel C Wassmer; Anna M Checkley

doi:10.1093/cid/ciad651

Adult Cerebral Malaria: Acute and Subacute Imaging Findings, Long-term Clinical Consequences

Clin Infect Dis. 2024 Feb 17;78(2):457-460. doi: 10.1093/cid/ciad651.

Authors

Charles Coughlan¹, Hans Rolf Jäger^{2

3

4}, David Brealey⁵, Francesco Carletti^{2

3}, Harpreet Hyare², Rajyabardhan Pattnaik⁶, Praveen K Sahu⁷, Sanjib Mohanty⁷, Sarah Logan¹, Angelika Hoffmann⁸, Samuel C Wassmer⁹, Anna M Checkley^{1

9}

Affiliations

¹ Department of Infectious Diseses, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
² Department of Radiology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
³ Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
⁴ Neuroradiological Academic Unit, Queen Square Institute of Neurology, London, United Kingdom.
⁵ Department of Intensive Care Medicine, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
⁶ Ispat General Hospital, Rourkela, India.
⁷ Center for the Study of Complex Malaria in India, Community Welfare Society Hospital, Rourkela, India.
⁸ University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
⁹ Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Abstract

Cerebral malaria is an important cause of mortality and neurodisability in endemic regions. We show magnetic resonance imaging (MRI) features suggestive of cytotoxic and vasogenic cerebral edema followed by microhemorrhages in 2 adult UK cases, comparing them with an Indian cohort. Long-term follow-up images correlate ongoing changes with residual functional impairment.

Keywords: MRI; cerebral malaria; malaria; neuro-disability; neuro-imaging.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain Edema* / etiology
Brain Edema* / pathology
Humans
Magnetic Resonance Imaging / adverse effects
Magnetic Resonance Imaging / methods
Malaria, Cerebral* / diagnostic imaging

Abstract

Publication types

MeSH terms

Grants and funding