RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection-Hints on Another Layer of Complexity

Vlatka Ivanišević; Lidia Žilić; Marina Čunko; Hana Fadiga; Ivana Munitić; Igor Jurak

doi:10.3390/v15102007

RNA Editing-Dependent and -Independent Roles of Adenosine Deaminases Acting on RNA Proteins in Herpesvirus Infection-Hints on Another Layer of Complexity

Viruses. 2023 Sep 27;15(10):2007. doi: 10.3390/v15102007.

Authors

Vlatka Ivanišević¹, Lidia Žilić¹, Marina Čunko¹, Hana Fadiga¹, Ivana Munitić¹, Igor Jurak¹

Affiliation

¹ Department of Biotechnology, University of Rijeka, 51000 Rijeka, Croatia.

Abstract

The Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons. RNA editing is the cornerstone of innate immunity that distinguishes between self and non-self (virus), and it is essential for normal regulation of cellular homeostasis. Although much is already known about the role of ADAR proteins in RNA virus infection, the role of ADAR proteins in herpesvirus infection remains largely unexplored. In this review, we provide several lines of evidence from studies of different herpesviruses for another level of complexity in regulating the already intricate biphasic life cycle of herpesviruses.

Keywords: ADAR; RNA editing; dsRNA; herpesvirus; innate immunity; latency; miRNA.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine / metabolism
Adenosine Deaminase* / metabolism
Herpesviridae Infections*
Humans
RNA Editing
RNA, Double-Stranded

Substances

Adenosine Deaminase
RNA, Double-Stranded
Adenosine

Grants and funding

This research was funded by Croatian Science Foundation, Grants IP-2020-02-2287 and DOK-2012-02-9152, and University of Rijeka support grant prirod-sp-23-502930 to I.J.