The Potential Hypoglycemic Competence of Low Molecular Weight Polysaccharides Obtained from Laminaria japonica

Aijun Tong; Dengwei Wang; Xiaoyan Liu; Zhiqun Li; Runfan Zhao; Bin Liu; Chao Zhao

doi:10.3390/foods12203809

The Potential Hypoglycemic Competence of Low Molecular Weight Polysaccharides Obtained from Laminaria japonica

Foods. 2023 Oct 17;12(20):3809. doi: 10.3390/foods12203809.

Authors

Aijun Tong^{1

2}, Dengwei Wang³, Xiaoyan Liu⁴, Zhiqun Li^{1

2}, Runfan Zhao⁵, Bin Liu^{1

2}, Chao Zhao^{1

2

6}

Affiliations

¹ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
² Marine Food Research and Development Center, Fuzhou Ocean Research Institute, Fuzhou 350002, China.
³ Department of Chronic and Noncommunicable Disease Control and Prevention, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350012, China.
⁴ Beijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
⁵ College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
⁶ College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Abstract

This study aimed to assess the hypoglycemic efficacy of low molecular weight polysaccharides fractions obtained from Laminaria japonica (LJOO) in a model of type 2 diabetes mellitus (T2DM) constructed using mice. Biochemical parameters were measured after 4 weeks of continuous gavage, and fasting blood glucose (FBG) concentrations were analyzed. Pathological changes in tissues were assessed. The intestinal contents were obtained for 16S rDNA high-throughput sequencing analysis and detection of short-chain fatty acids (SCFAs). LJOO lowered FBG and insulin concentrations. It altered the gut microbiota composition, as evidenced by enriched probiotic bacteria, along with an increase in the Bacteroidetes/Firmicutes ratio and a decrease in the population of harmful bacteria. LJOO stimulated the growth of SCFA-producing bacteria, thereby increasing cecal SCFAs levels. LJOO can potentially aid in alleviating T2DM and related gut microbiota dysbiosis. LJOO may be used as a food supplement for patients with T2DM.

Keywords: Laminaria japonica polysaccharide; gut microbiota; low molecular weight; type 2 diabetes.

Abstract

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