Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction

Simon W Rabkin; Chenille N Wong

doi:10.3390/biomedicines11102815

Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction

Biomedicines. 2023 Oct 17;11(10):2815. doi: 10.3390/biomedicines11102815.

Authors

Simon W Rabkin^{1

2}, Chenille N Wong¹

Affiliations

¹ Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
² Division of Cardiology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

Abstract

This review will focus on epigenetic modifications utilizing the DNA methylation mechanism, which is potentially involved in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). The putative pathways of HFpEF will be discussed, specifically myocardial fibrosis, myocardial inflammation, sarcoplasmic reticulum Ca²⁺-ATPase, oxidative-nitrosative stress, mitochondrial and metabolic defects, as well as obesity. The relationship of HFpEF to aging and atrial fibrillation will be examined from the perspective of DNA methylation.

Keywords: DNA methylation; cardiac fibrosis; cardiac metabolism; heart failure with preserved ejection fraction; obesity.

Publication types

Review

Grants and funding

This research received no external funding.