Recent Advances in Molecular and Cellular Functions of S100A10

Gillian C Okura; Alamelu G Bharadwaj; David M Waisman

doi:10.3390/biom13101450

Recent Advances in Molecular and Cellular Functions of S100A10

Biomolecules. 2023 Sep 26;13(10):1450. doi: 10.3390/biom13101450.

Authors

Gillian C Okura¹, Alamelu G Bharadwaj^{1

2}, David M Waisman^{1

2}

Affiliations

¹ Department of Pathology, Dalhousie University, Halifax, NS B3H 1X5, Canada.
² Departments of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS B3H 1X5, Canada.

Abstract

S100A10 (p11, annexin II light chain, calpactin light chain) is a multifunctional protein with a wide range of physiological activity. S100A10 is unique among the S100 family members of proteins since it does not bind to Ca²⁺, despite its sequence and structural similarity. This review focuses on studies highlighting the structure, regulation, and binding partners of S100A10. The binding partners of S100A10 were collated and summarized.

Keywords: Ca2+-binding; S100A10; cancer; depression; fibrinolysis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Annexin A2* / metabolism
Annexins
Cell Physiological Phenomena
S100 Proteins* / metabolism

Substances

S100 Proteins
Annexin A2
Annexins

Grants and funding

162283/CIHR/Canada