Subxiphoid versus lateral intercostal thoracoscopic thymectomy for suspected thymoma: Results of a randomized controlled trial

Shuai Wang; Xinyu Yang; Jiahao Jiang; Miao Lin; Hong Fan; Zhilong Zhang; Hongwei Xia; Hao Wang; Fei Liang; Jianyong Ding; Lijie Tan

doi:10.1016/j.jtcvs.2023.10.040

Subxiphoid versus lateral intercostal thoracoscopic thymectomy for suspected thymoma: Results of a randomized controlled trial

J Thorac Cardiovasc Surg. 2023 Oct 27:S0022-5223(23)00997-2. doi: 10.1016/j.jtcvs.2023.10.040. Online ahead of print.

Authors

Shuai Wang¹, Xinyu Yang¹, Jiahao Jiang¹, Miao Lin¹, Hong Fan², Zhilong Zhang³, Hongwei Xia⁴, Hao Wang⁵, Fei Liang⁶, Jianyong Ding⁷, Lijie Tan⁸

Affiliations

¹ Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China.
² Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Thoracic Surgery, Xiamen Branch, Zhongshan Hospital, Fudan University, Shanghai, China.
³ Department of Thoracic Surgery, Xuhui Central Hospital, Shanghai, China.
⁴ Department of Thoracic Surgery, Qingpu Central Hospital, Shanghai, China.
⁵ Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.
⁶ Clinical Statistics Center, Zhongshan Hospital, Fudan University, Shanghai, China.
⁷ Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Thoracic Surgery, Qingpu Central Hospital, Shanghai, China. Electronic address: ding.jianyong@zs-hospital.sh.cn.
⁸ Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: Lijie.tan@hotmail.com.

PMID: 37890660
DOI: 10.1016/j.jtcvs.2023.10.040

Abstract

Objective: This trial was to evaluate the efficacy of subxiphoid approach thoracoscopic thymectomy for postoperative pain control and length of hospital stay compared with a lateral intercostal approach thoracoscopic thymectomy.

Methods: This multicenter, open-label, randomized clinical superiority trial enrolled 101 eligible participants clinically diagnosed with Masaoka-Koga I-II thymoma between August 15, 2021, and February 15, 2022. Each enrolled participant was randomized and underwent subxiphoid approach thoracoscopic thymectomy or lateral intercostal approach thoracoscopic thymectomy. A per-protocol analysis for each coprimary outcome was performed in addition to the main intention-to-treat analysis.

Results: In the analysis for the coprimary outcomes, the pain Visual Analog Scale score area under the curve at 0 to 7 days was lower in the subxiphoid approach thoracoscopic thymectomy group than in the lateral intercostal approach thoracoscopic thymectomy group (difference, -4.82; 98.3% CI, -8.84 to -0.80). However, there was no significant difference between the 2 groups in the length of hospital stay (difference, 0.318; 98.3% CI, -0.190 to 0.825) or cumulative opioid consumption after surgery (difference, -4.630; 98.3% CI, -9.530 to 0.272). All patients underwent complete resection, and there was no significant difference (7.84% vs 8.00%, P = 1.000) in the rate of complications between the 2 groups. No recurrence or death occurred in the postoperative 6 months.

Conclusions: This study found improved pain and similar length of hospital stay associated with the subxiphoid approach compared with the lateral intercostal approach in patients with suspected Masaoka-Koga I-II thymoma.

Keywords: lateral intercostal approach; pain management; subxiphoid approach; thymectomy; thymoma.