Mitochondrial control of antigen presentation in cancer cells

Ruth Soler-Agesta; Alberto Anel; Lorenzo Galluzzi

doi:10.1016/j.ccell.2023.10.001

Mitochondrial control of antigen presentation in cancer cells

Cancer Cell. 2023 Nov 13;41(11):1849-1851. doi: 10.1016/j.ccell.2023.10.001. Epub 2023 Oct 26.

Authors

Ruth Soler-Agesta¹, Alberto Anel², Lorenzo Galluzzi³

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Apoptosis, Immunity and Cancer Group, Department of Biochemistry and Molecular and Cell Biology, University of Zaragoza/Aragón Health Research Institute, Zaragoza, Spain.
² Apoptosis, Immunity and Cancer Group, Department of Biochemistry and Molecular and Cell Biology, University of Zaragoza/Aragón Health Research Institute, Zaragoza, Spain.
³ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. Electronic address: deadoc80@gmail.com.

PMID: 37890494
DOI: 10.1016/j.ccell.2023.10.001

Abstract

Cytotoxic T lymphocytes recognize and kill cancer cells when the latter present antigenic epitopes complexed with MHC class I molecules on their surface. In a recent Science paper, Mangalhara et al. show that alterations of the mitochondrial electron flow upregulate multiple factors involved in antigen presentation via a succinate-dependent epigenetic mechanism.

Publication types

Comment

MeSH terms

Antigen Presentation*
Histocompatibility Antigens Class I
Humans
Neoplasms* / genetics
T-Lymphocytes, Cytotoxic

Substances

Histocompatibility Antigens Class I