Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells

Mar Drugs. 2023 Oct 8;21(10):529. doi: 10.3390/md21100529.

Abstract

Five new eudensamane-type sesquiterpene lactones, clasamanes A-E (1-5), three new dolabellane-type diterpenes, clabellanes A-C (6-8), and fifteen known compounds (9-23) were isolated from the ethanolic extract of Taiwanese soft coral Clavularia spp. The structures of all undescribed components (1-8) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations. The cytotoxic activities of all isolated marine natural products were evaluated. Compound 7 showed a significant cytotoxic effect against oral cancer cell line (Ca9-22) with an IC50 value of 7.26 ± 0.17 μg/mL.

Keywords: Clavularia spp.; cytotoxicity; dolabellane; eudensamane-type sesquiterpene lactone.

MeSH terms

  • Animals
  • Anthozoa* / chemistry
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Diterpenes* / chemistry
  • Diterpenes* / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Mouth Neoplasms* / drug therapy
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Diterpenes