Investigations of Single-Subunit tRNA Methyltransferases from Yeast

Zhongyuan Wang; Xiangbin Xu; Xinhai Li; Jiaqi Fang; Zhenkuai Huang; Mengli Zhang; Jiameng Liu; Xiaoting Qiu

doi:10.3390/jof9101030

Investigations of Single-Subunit tRNA Methyltransferases from Yeast

J Fungi (Basel). 2023 Oct 19;9(10):1030. doi: 10.3390/jof9101030.

Authors

Zhongyuan Wang^{1

2

3}, Xiangbin Xu^{2

3}, Xinhai Li^{1

2

3}, Jiaqi Fang^{1

2

3}, Zhenkuai Huang^{1

2

3}, Mengli Zhang^{1

2

3}, Jiameng Liu^{1

2

3}, Xiaoting Qiu^{1

2

3}

Affiliations

¹ Ministry of Education Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ningbo 315800, China.
² College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, China.
³ Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Centre, Ningbo University, Ningbo 315800, China.

Abstract

tRNA methylations, including base modification and 2'-O-methylation of ribose moiety, play critical roles in the structural stabilization of tRNAs and the fidelity and efficiency of protein translation. These modifications are catalyzed by tRNA methyltransferases (TRMs). Some of the TRMs from yeast can fully function only by a single subunit. In this study, after performing the primary bioinformatic analyses, the progress of the studies of yeast single-subunit TRMs, as well as the studies of their homologues from yeast and other types of eukaryotes and the corresponding TRMs from other types of organisms was systematically reviewed, which will facilitate the understanding of the evolutionary origin of functional diversity of eukaryotic single-subunit TRM.

Keywords: Trm10p; tRNA methylation; yeast single-subunit TRM.

Publication types

Review

Abstract

Publication types

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