Magnetic Shape-Memory Heuslers Turn to Bio: Cytocompatibility of Ni-Mn-Ga Films and Biomedical Perspective

ACS Appl Bio Mater. 2023 Nov 20;6(11):5009-5017. doi: 10.1021/acsabm.3c00691. Epub 2023 Oct 27.

Abstract

Magnetic shape-memory (MSM) Heuslers have attracted great attention in recent years for both caloric and magnetomechanical applications. Thanks to their multifunctional properties, they are also promising for a vast variety of biomedical applications. However, this topic has been rarely investigated so far. In this communication, we present the first report on the absence of cytotoxicity of MSM Heuslers in Ni-Mn-Ga epitaxial thin films and the perspective toward bioapplications. Qualitative and quantitative biological characterizations reveal that Ni-Mn-Ga films can promote the adhesion and proliferation of human fibroblasts without eliciting any cytotoxic effect. Additionally, our findings show that the morphology, composition, microstructure, phase transformation, and magnetic characteristics of the films are well preserved after the biological treatments, making the material a promising candidate for further investigations.

Keywords: Heusler alloy; cell adhesion; cytotoxicity; epitaxial Ni−Mn−Ga film; human fibroblast cell; magnetic shape memory; proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fibroblasts*
  • Humans
  • Magnetic Phenomena*