Defining the commonalities between post-transcriptional and post-translational modification communities

Zachary T Baumer; Luke Erber; Elizabeth Jolley; Sheldon Lawrence; Chuwei Lin; Shino Murakami; Veronica Perez; Wil Prall; Cassandra Schaening-Burgos; Megan Sylvia; Sixue Chen; Brian D Gregory

doi:10.1016/j.tibs.2023.09.011

Defining the commonalities between post-transcriptional and post-translational modification communities

Trends Biochem Sci. 2024 Mar;49(3):185-188. doi: 10.1016/j.tibs.2023.09.011. Epub 2023 Oct 24.

Authors

Affiliations

¹ Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80305, USA.
² Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66044, USA.
³ Department of Chemistry, Center for RNA Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
⁴ Department of Biology, Oxford College of Emory University, Oxford, GA 30054, USA.
⁵ Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
⁶ Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.
⁷ Horticultural Sciences Department, University of Florida, Gainesville, FL 32611, USA.
⁸ Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁹ Remix Therapeutics, Watertown, MA 02472, USA.
¹⁰ Intercollege Graduate Degree Program in Plant Biology, Department of Biology, and Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.
¹¹ Department of Biology, University of Mississippi, University, MS 38677, USA. Electronic address: schen8@olemiss.edu.
¹² Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bdgregor@sas.upenn.edu.

PMID: 37884411
DOI: 10.1016/j.tibs.2023.09.011

Abstract

Post-transcriptional modifications of RNA (PRMs) and post-translational modifications of proteins (PTMs) are important regulatory mechanisms in biological processes and have many commonalities. However, the integration of these research areas is lacking. A recent discussion identified the priorities, areas of emphasis, and necessary technologies to advance and integrate these areas of study.

MeSH terms

Protein Processing, Post-Translational*
Proteins*
RNA

Substances

Proteins
RNA