Glaesserella parasuis QseBC two-component system senses epinephrine and regulates capD expression

Microbiol Spectr. 2023 Dec 12;11(6):e0150823. doi: 10.1128/spectrum.01508-23. Epub 2023 Oct 26.

Abstract

The key bacterial pathogen Glaesserella parasuis, which can cause Glässer's disease, has caused significant financial losses to the swine industry worldwide. Capsular polysaccharide (CPS) is an important virulence factor for bacteria, providing the ability to avoid recognition and killing by the host immune system. Exploring the alteration of CPS synthesis in G. parasuis in response to epinephrine stimulation can lay the groundwork for revealing the pathogenic mechanism of G. parasuis as well as providing ideas for Glässer's disease control.

Keywords: Glaesserella parasuis; capsular polysaccharide; epinephrine; two-component system.

MeSH terms

  • Animals
  • Haemophilus Infections* / microbiology
  • Haemophilus Infections* / veterinary
  • Haemophilus parasuis* / genetics
  • Swine
  • Swine Diseases* / microbiology
  • Virulence Factors

Substances

  • Virulence Factors