Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy

Yuxiang Zhang; Wei Ju; Hong Zhang; Liu Mengyun; Weiliang Shen; Xiao Chen

doi:10.1186/s13287-023-03431-3

Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy

Stem Cell Res Ther. 2023 Oct 26;14(1):307. doi: 10.1186/s13287-023-03431-3.

Authors

Yuxiang Zhang^#^{1

2}, Wei Ju^#³, Hong Zhang^#^{2

3

4

5}, Liu Mengyun^{3

4

6}, Weiliang Shen^{7

8

9

10}, Xiao Chen^{11

12

13

14}

Affiliations

¹ Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine and Department of Orthopedic Surgery of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
³ Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.
⁴ Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China.
⁵ China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China.
⁶ Dr. Li Dak Sum-Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
⁷ Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China. wlshen@zju.edu.cn.
⁸ Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China. wlshen@zju.edu.cn.
⁹ China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China. wlshen@zju.edu.cn.
¹⁰ Dr. Li Dak Sum-Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. wlshen@zju.edu.cn.
¹¹ Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China. chenxiao-610@zju.edu.cn.
¹² Department of Sports Medicine, Zhejiang University School of Medicine, Hangzhou, China. chenxiao-610@zju.edu.cn.
¹³ China Orthopedic Regenerative Medicine Group (CORMed), Hangzhou, China. chenxiao-610@zju.edu.cn.
¹⁴ Dr. Li Dak Sum-Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. chenxiao-610@zju.edu.cn.

^# Contributed equally.

Abstract

Tendinopathy is a debilitating and crippling syndrome resulting from the degeneration of tendon tissue, leading to loss of mechanical properties and function, and eventual tendon rupture. Unfortunately, there is currently no treatment for tendinopathy that can prevent or delay its progression. Exosomes are small extracellular vesicles that transport bioactive substances produced by cells, such as proteins, lipids, mRNAs, non-coding RNAs, and DNA. They can generate by mesenchymal stem cells (MSCs) throughout the body and play a role in intercellular communication and regulation of homeostasis. Recent research suggests that MSCs-derived exosomes (MSCs-exos) may serve as useful therapeutic candidates for promoting tendon healing. This review focuses on the function and mechanisms of MSCs-exos in tendinopathy treatment and discusses their potential application for treating this condition.

Keywords: Exosomes; Mesenchymal stem cells; Tendinopathy; Therapeutics.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Exosomes* / metabolism
Extracellular Vesicles*
Humans
Mesenchymal Stem Cells* / metabolism
Tendinopathy* / therapy
Wound Healing