Delayed myelopathy in a child following organic phosphate poisoning

BMJ Case Rep. 2023 Oct 24;16(10):e253456. doi: 10.1136/bcr-2022-253456.

Abstract

We report a rare manifestation of delayed organophosphate (OP) poisoning in a male patient in his early childhood. After initially presenting with a cholinergic crisis after OP exposure, the patient returned 3 weeks later with paraparesis and difficulty with bladder control. The results of the MRI of the spine and brain as well as the nerve conduction studies were normal. Myelopathy induced by OP poisoning should be considered in any patient with a history of OP exposure and a presentation of paraparesis. At most recent follow-up, the patient had full bladder control and could walk without assistance. However, he demonstrated circumduction while walking with upper motor neuron signs. Furthermore, he had mild Achilles tendon contractures on both sides. To enable early detection, neurologists and paediatricians should be aware of this uncommon complication of OP poisoning which may influence neurological outcome.

Keywords: Neurology (drugs and medicines); Paediatrics (drugs and medicines); Poisoning.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Humans
  • Male
  • Organophosphate Poisoning*
  • Organophosphates
  • Paraparesis
  • Poisoning* / diagnosis
  • Spinal Cord Diseases* / chemically induced
  • Spinal Cord Diseases* / diagnostic imaging

Substances

  • Organophosphates