Bioengineered nanotechnology for nucleic acid delivery

Yang Zhang; Jing Luo; Xiran Gui; Yating Zheng; Eric Schaar; Gang Liu; Jinjun Shi

doi:10.1016/j.jconrel.2023.10.034

Bioengineered nanotechnology for nucleic acid delivery

J Control Release. 2023 Dec:364:124-141. doi: 10.1016/j.jconrel.2023.10.034. Epub 2023 Oct 27.

Authors

Yang Zhang¹, Jing Luo², Xiran Gui³, Yating Zheng³, Eric Schaar⁴, Gang Liu⁵, Jinjun Shi⁶

Affiliations

¹ State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China; Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² Department of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
³ State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
⁴ Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
⁵ State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China. Electronic address: gangliu.cmitm@xmu.edu.cn.
⁶ Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jshi@bwh.harvard.edu.

Abstract

Nucleic acid-based therapy has emerged as a promising therapeutic approach for treating various diseases, such as genetic disorders, cancers, and viral infections. Diverse nucleic acid delivery systems have been reported, and some, including lipid nanoparticles, have exhibited clinical success. In parallel, bioengineered nucleic acid delivery nanocarriers have also gained significant attention due to their flexible functional design and excellent biocompatibility. In this review, we summarize recent advances in bioengineered nucleic acid delivery nanocarriers, focusing on exosomes, cell membrane-derived nanovesicles, protein nanocages, and virus-like particles. We highlight their unique features, advantages for nucleic acid delivery, and biomedical applications. Furthermore, we discuss the challenges that bioengineered nanocarriers face towards clinical translation and the possible avenues for their further development. This review ultimately underlines the potential of bioengineered nanotechnology for the advancement of nucleic acid therapy.

Keywords: Bioengineered nanotechnology; Cell membrane-derived nanovesicle; Exosome; Nucleic acid delivery; Protein nanocage; Virus-like particle.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Drug Delivery Systems
Nanoparticles*
Nanotechnology
Nucleic Acids*
Proteins

Substances

Nucleic Acids
Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding