An increase in invasive group A Streptococcus infection was detected in the northeast of Spain in November 2022. A postpandemic decline in the diversity of circulating emm types involved in invasive group A Streptococcus was observed, along with the emergence of emm49 in this geographic area.
Keywords: Spain; Streptococcus pyogenes; bacteria; emm typing; group A Streptococcus; invasive infection; streptococci.