The Faraday Discussion 'Astrochemistry at high resolution' was held at the Space Telescope Science Institute, Baltimore, United States, and online from May 31-June 2, 2023. The meeting brought together observers, modellers, and experimentalists at different career stages and from different countries to discuss advancements in astrochemistry resulting from improved spatial resolution, spectral resolution, and sensitivity. This conference report provides highlights of the meeting and summaries of the talks presented.