Genomic characterisation of a novel KPC-98-producing clinical Klebsiella pneumoniae strain conferring resistance to ceftazidime/avibactam

Gabriel Mendes; Maria Leonor Santos; João F Ramalho; Ana Bruschy-Fonseca; Luís Lito; Diogo Mendes-Pedro; Aida Duarte; José Melo-Cristino; Cátia Caneiras

doi:10.1016/j.ijantimicag.2023.107013

Genomic characterisation of a novel KPC-98-producing clinical Klebsiella pneumoniae strain conferring resistance to ceftazidime/avibactam

Int J Antimicrob Agents. 2023 Dec;62(6):107013. doi: 10.1016/j.ijantimicag.2023.107013. Epub 2023 Oct 22.

Authors

Gabriel Mendes¹, Maria Leonor Santos¹, João F Ramalho¹, Ana Bruschy-Fonseca², Luís Lito², Diogo Mendes-Pedro³, Aida Duarte⁴, José Melo-Cristino⁵, Cátia Caneiras⁶

Affiliations

¹ Microbiology Research Laboratory on Environmental Health (EnviHealthMicro Lab), Institute of Environmental Health (ISAMB), Associate Laboratory TERRA, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisbon, Portugal.
² Microbiology Laboratory, Clinical Pathology Department, Centro Hospitalar Universitário Lisboa Norte, 1649-035, Lisbon, Portugal.
³ Microbiology Research Laboratory on Environmental Health (EnviHealthMicro Lab), Institute of Environmental Health (ISAMB), Associate Laboratory TERRA, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisbon, Portugal; Infectious Diseases Department, Centro Hospitalar Universitário Lisboa Norte, 1649-035, Lisbon, Portugal.
⁴ Faculty of Pharmacy, Universidade de Lisboa, 1649-033, Lisbon, Portugal; Egas Moniz Interdisciplinary Research Center (CiiEM), Egas Moniz School of Health and Science, 2829-511, Caparica, Portugal.
⁵ Microbiology Laboratory, Clinical Pathology Department, Centro Hospitalar Universitário Lisboa Norte, 1649-035, Lisbon, Portugal; Institute of Microbiology, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisbon, Portugal.
⁶ Microbiology Research Laboratory on Environmental Health (EnviHealthMicro Lab), Institute of Environmental Health (ISAMB), Associate Laboratory TERRA, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisbon, Portugal; Egas Moniz Interdisciplinary Research Center (CiiEM), Egas Moniz School of Health and Science, 2829-511, Caparica, Portugal; Institute of Preventive Medicine and Public Health, Faculdade de Medicina, Universidade de Lisboa, 1649-028, Lisbon, Portugal. Electronic address: ccaneiras@medicina.ulisboa.pt.

PMID: 37875180
DOI: 10.1016/j.ijantimicag.2023.107013

No abstract available

Publication types

Letter

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Azabicyclo Compounds / pharmacology
Bacterial Proteins / genetics
Ceftazidime* / pharmacology
Drug Combinations
Genomics
Humans
Klebsiella Infections* / drug therapy
Klebsiella pneumoniae / genetics
Microbial Sensitivity Tests
beta-Lactamases / genetics

Substances

Ceftazidime
avibactam
Anti-Bacterial Agents
Azabicyclo Compounds
Drug Combinations
beta-Lactamases
Bacterial Proteins