Cytotoxic xanthones from Garcinia pedunculata fruits

Phytochemistry. 2024 Jan:217:113898. doi: 10.1016/j.phytochem.2023.113898. Epub 2023 Oct 22.

Abstract

Eight previously undescribed and seven known xanthones were isolated from the fruits of Garcinia pedunculata Roxb. The structures were identified by a variety of spectroscopic methods as well as by comparison with the literature. The isolates showed appreciable cytotoxicity against three human tumor cell lines (HepG2, A549, and MCF-7). Pedunculaxanthone G exhibited inhibitory activities with IC50 values of 12.41, 16.51, and 15.45 μM against the cancer cell lines and induced cell apoptosis in HepG2 cells.

Keywords: Clusiaceae xanthones; Cytotoxicity; Garcinia pedunculata roxb.

MeSH terms

  • Animals
  • Antineoplastic Agents*
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Cell Line, Tumor
  • Fruit
  • Garcinia* / chemistry
  • Humans
  • Molecular Structure
  • Thoracica*
  • Xanthones* / chemistry
  • Xanthones* / pharmacology

Substances

  • Xanthones
  • Antineoplastic Agents, Phytogenic
  • Antineoplastic Agents