mSphere of Influence: Coordinating effective clearance of bacterial bloodstream infections

Caitlyn L Holmes

doi:10.1128/msphere.00521-23

mSphere of Influence: Coordinating effective clearance of bacterial bloodstream infections

mSphere. 2023 Dec 20;8(6):e0052123. doi: 10.1128/msphere.00521-23. Epub 2023 Oct 24.

Author

Caitlyn L Holmes^{1

2}

Affiliations

¹ Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
² Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Abstract

Caitlyn Holmes works in the field of bacterial pathogenesis and host-pathogen interactions. In this mSphere of Influence article, she reflects on how the papers "Innate Lymphocyte/Ly6C^hi Monocyte Crosstalk Promotes Klebsiella pneumoniae Clearance" by Xiong et al. (H. Xiong, J. W. Keith, D. W. Samilo, R. A. Carter, et al., Cell 165:679-89, 2016, https://doi.org/10.1016/j.cell.2016.03.017) and "Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity" by Broadley et al. (S. P. Broadley, A. Plaumann, R. Coletti, C. Lehmann, et al., Cell Host Microbe 20:36-48, 2016, https://doi.org/10.1016/j.chom.2016.05.023) impacted her research by highlighting the tangled web of immune responses that influence bacterial bloodstream infections.

Keywords: Gram-negative bacteria; Klebsiella; bacteremia; bloodstream infections.

MeSH terms

Bacteria
Bacterial Infections*
Host-Pathogen Interactions
Humans
Monocytes
Sepsis*