A free radical nitration of olefins with NaNO2/I2O5

Xuan Huang; Huichao You; Fang Fang; Fan Wang; Zhong-Quan Liu

doi:10.1039/d3cc04275h

A free radical nitration of olefins with NaNO₂/I₂O₅

Chem Commun (Camb). 2023 Nov 7;59(89):13352-13354. doi: 10.1039/d3cc04275h.

Authors

Xuan Huang¹, Huichao You¹, Fang Fang¹, Fan Wang¹, Zhong-Quan Liu¹

Affiliation

¹ Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China. liuzhq@lzu.edu.cn.

PMID: 37872833
DOI: 10.1039/d3cc04275h

Abstract

We demonstrated herein an I₂O₅-mediated radical nitration of olefins with NaNO₂. A variety of (E)-nitroolefins can be synthesized in high yields and chemoselectivity.