The intellectual base and global trends in inflammation of diabetic kidney disease: a bibliometric analysis

Ren Fail. 2023;45(2):2270061. doi: 10.1080/0886022X.2023.2270061. Epub 2023 Oct 23.

Abstract

Diabetic kidney disease (DKD) is a severe complication of diabetes mellitus (DM). The literature on DKD inflammation research has experienced substantial growth. However, there is a lack of bibliometric analyses. This study aimed to examine the existing research on inflammation in DKD by analyzing articles published in the Web of Science Core Collection (WOSCC) over the past 30 years. We conducted a visualization analysis using several software, including CiteSpace and VOSviewer. We found that the literature on inflammation research in DKD has experienced substantial growth, indicating a rising interest in this developing area of study. In this field, Navarro-Gonzalez, JF is the most frequently cited author, Kidney International is the most frequently cited journal, China had the highest number of publications in the field of DKD inflammation, and Monash University emerged as the institution with the most published research. The research area on inflammation in DKD primarily centers around the investigation of 'Glycation end-products', 'chronic kidney disease', and 'diabetic nephropathy'. The emerging research trends in this field will focus on the 'Gut microbiota', 'NLRP3 inflammasome', 'autophagy', 'pyroptosis', 'sglt2 inhibitor', and 'therapeutic target'. Future research on DKD may focus on further exploring the inflammatory response, identifying specific therapeutic targets, studying biomarkers, investigating stem cell therapy and tissue engineering, and exploring gene therapy and gene editing. In summary, this study examines the main areas of study, frontiers, and trends in DKD inflammation, which have significant implications for future research.

Keywords: Bibliometric analysis; diabetic kidney disease; inflammation; research trends.

Publication types

  • Review

MeSH terms

  • Autophagy
  • Bibliometrics
  • Diabetes Mellitus*
  • Diabetic Nephropathies* / etiology
  • Humans
  • Inflammation
  • Kidney

Grants and funding

This work was supported by a grant from the Outstanding-Youth Cultivation Project for Union Foundation of Yunnan Applied Basic Research Projects (Project Number: 202201AY070001-044), Reserve Talents Project for Young and Middle-aged Academic and Technical Leaders of Yunnan Province (Project Number: 202205AC160062), Special Project for Selecting High-level Scientific and Technological Talents and Innovation Team of Yunnan Province – Technical Innovation Talent Training Target Project (Project Number: 202305AD160007), 535 Talent Project of First Affiliated Hospital of Kunming Medical University (Project Number: 2022535D06), and the Scientific Research Fund of the Department of Education of Yunnan Province (Project Number: 2023Y0809).