Pneumonia with Intense 68Ga-FAPI Uptake Mimicking Metastasis on 68Ga-FAPI PET/CT in a Patient with Rectal Cancer

Özge Erol Fenercioğlu; Ediz Beyhan; Nilay Şengül Samancı; Tevfik Fikret Çermik; Nurhan Ergül

doi:10.4274/mirt.galenos.2023.07830

Pneumonia with Intense ⁶⁸Ga-FAPI Uptake Mimicking Metastasis on ⁶⁸Ga-FAPI PET/CT in a Patient with Rectal Cancer

Mol Imaging Radionucl Ther. 2023 Oct 20;32(3):237-238. doi: 10.4274/mirt.galenos.2023.07830.

Authors

Özge Erol Fenercioğlu¹, Ediz Beyhan¹, Nilay Şengül Samancı², Tevfik Fikret Çermik¹, Nurhan Ergül¹

Affiliations

¹ University of Health Sciences Türkiye, İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Türkiye.
² University of Health Sciences Türkiye, İstanbul Training and Research Hospital, Clinic of Medical Oncology, İstanbul, Türkiye.

Abstract
in English, Turkish

A 70-year-old man with newly diagnosed rectum adenocarcinoma was referred to ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) for staging, and ⁶⁸Ga-fibroblast activation protein inhibitor (FAPI)-04 PET/CT for ongoing trial. Both ¹⁸F-FDG PET/CT and ⁶⁸Ga-FAPI-04 PET/CT showed intense uptake in the primary rectal tumor, and also in nodular areas in the right lung. Due to intense ⁶⁸Ga-FAPI-04 and ¹⁸F-FDG uptake, the lung lesions were considered as metastases. However the lesions were reduced in size on CT after 20 days antibiotherapy and diagnosed as pneumonia.

Yeni rektum kanseri tanılı 70 yaşında erkek hasta evreleme amacıyla ¹⁸F-florodeoksiglukoz pozitron emisyon tomografisi/bilgisayarlı tomografiye (¹⁸F-FDG PET/BT) ve devam eden çalışma için ⁶⁸Ga-fibroblast aktivasyon proteini inhibitörü (FAPI)-04 PET/BT’ye gönderildi. Hem ¹⁸F-FDG PET/BT hem de ⁶⁸Ga-FAPI-04 PET/BT’de primer rektal tümörde ve sağ akciğerde yer alan nodüler alanlarda yoğun radyofarmasötik tutulumu izlendi. Bu yüzden akciğer lezyonları metastaz olarak değerlendirildi. Antibiyoterapiden 20 gün sonra lezyonlar BT’de rezolüsyona uğradı ve tanı pnömoni olarak doğrulandı.

Keywords: 68Ga-FAPI; CT; PET/CT; pneumonia.

Abstract in English, Turkish

Abstract
in English, Turkish