Dual trigger for final oocyte maturation in expected normal responders with a high immature oocyte rate: a randomized controlled trial

Meng-Han Yan; Zhen-Gao Sun; Jing-Yan Song

doi:10.3389/fmed.2023.1254982

Dual trigger for final oocyte maturation in expected normal responders with a high immature oocyte rate: a randomized controlled trial

Front Med (Lausanne). 2023 Oct 5:10:1254982. doi: 10.3389/fmed.2023.1254982. eCollection 2023.

Authors

Meng-Han Yan¹, Zhen-Gao Sun^{1

2}, Jing-Yan Song^{1

2}

Affiliations

¹ The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
² Reproductive Center of Integrated Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.

Abstract

Objective: To evaluate whether dual trigger could improve reproductive outcomes in women with low oocyte maturation rates compare to human chorionic gonadotropin (hCG) trigger.

Methods: This study included expected normal ovarian responders younger than 40 years old whose immature oocyte rate in the previous cycle was more than 50% at the reproductive center from July 2021 to November 2022. A total of 73 patients were enrolled at trigger, including 34 in the hCG trigger group and 39 in the dual trigger group (co-administration of gonadotrophin releasing hormone (GnRH) agonist and hCG, 40 and 34 h prior to oocyte retrieval, respectively). The primary outcome was oocyte maturation rate.

Results: There was no significant difference in the number of oocytes retrieved between the two study groups, but the oocyte maturation rate was higher in dual trigger group (84.0% [14.0%] vs. 55.5% [19.8%], p < 0.001). Moreover, there were also higher cumulative pregnancy rate (69.4% vs. 40.0%, p = 0.035) and cumulative live birth rate (66.7% vs. 36.0%, p = 0.022) in dual trigger group.

Conclusion: For normal responders with low oocyte maturation rates, the dual trigger may be more effective than the conventional hCG trigger.

Clinical trial registration: ClinicalTrials.gov, identifier ChiCTR2100049292.

Keywords: MII oocytes; dual trigger; gonadotropin releasing hormone agonist; human chorionic gonadotropin; normal ovarian responder.