Case Report: Resolution of remitting seronegative symmetrical synovitis with pitting edema during nivolumab therapy for gastric cancer

Hirofumi Ohmura; Moe Kondo; Masato Uenomachi; Hiroshi Ariyama; Mamoru Ito; Kenji Tsuchihashi; Masahiro Ayano; Hiroaki Niiro; Koichi Akashi; Eishi Baba

doi:10.3389/fonc.2023.1260818

Case Report: Resolution of remitting seronegative symmetrical synovitis with pitting edema during nivolumab therapy for gastric cancer

Front Oncol. 2023 Oct 5:13:1260818. doi: 10.3389/fonc.2023.1260818. eCollection 2023.

Authors

Affiliations

¹ Department of Oncology and Social Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
² Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
³ Department of Diabetes Mellitus and Endocrinology, Nanpuh Hospital, Kagoshima, Japan.
⁴ Department of Oncology, Kitakyushu Municipal Medical Center, Fukuoka, Japan.
⁵ Department of Medical Education, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan.

Abstract

The anti-programmed cell death-1 (PD-1) antibody nivolumab has been shown to significantly prolong the survival of patients with unresectable advanced or recurrent gastric cancer (AGC). However, immune-related adverse events (irAEs), which show different profiles from those of cytotoxic agents or conventional molecular-targeted drugs including tyrosine kinase inhibitors, have been reported. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare autoimmune disorder with acute-onset, rheumatoid factor-negative, symmetric synovitis associated with limb edema observed in elderly persons. A case of RS3PE syndrome that developed after administration of nivolumab for advanced gastric cancer is reported. This is the first report of a case of RS3PE syndrome as an irAE caused by nivolumab in a patient with gastric cancer.

Keywords: RS3PE; gastric cancer; irAE; nivolumab; pathology.

Publication types

Case Reports

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article.