How Extracellular Nano-Vesicles Can Play a Role in Sepsis? An Evidence-Based Review of the Literature

Xiaolin Jin; Haiyan Sun; Lina Yang

doi:10.2147/IJN.S427116

How Extracellular Nano-Vesicles Can Play a Role in Sepsis? An Evidence-Based Review of the Literature

Int J Nanomedicine. 2023 Oct 16:18:5797-5814. doi: 10.2147/IJN.S427116. eCollection 2023.

Authors

Xiaolin Jin¹, Haiyan Sun², Lina Yang^{1

3}

Affiliations

¹ Department of International Physical Examination Center, The First Hospital of China Medical University, Shengyang, People's Republic of China.
² Department of Endodontics, School of Stomatology, China Medical University, Shenyang, People's Republic of China.
³ Department of Geriatrics, The First Hospital of China Medical University, Shenyang, People's Republic of China.

Abstract

Sepsis is a systemic inflammatory reaction caused by infection. Severe sepsis can lead to multiple organ dysfunction, with a high incidence rate and mortality. The molecular pathogenesis of sepsis is complex and diverse. In recent years, with further study of the role of extracellular vesicles (EVs) in inflammatory diseases, it has been found that EVs play a dual role in the imbalance of inflammatory response in sepsis. Due to the great advantages such as lower toxicity, lower immunogenicity compared with stem cells and better circulation stability, EVs are increasingly used for the diagnosis and treatment of sepsis. The roles of EVs in the pathogenesis, diagnosis and treatment of sepsis were summarized to guide further clinical studies.

Keywords: exosome; extracellular vesicles; inflammatory response; microvesicle; sepsis.

Publication types

Review

MeSH terms

Extracellular Vesicles* / pathology
Humans
Inflammation
Sepsis* / diagnosis
Sepsis* / pathology
Stem Cells

Grants and funding

This work was funded by the National Natural Science Foundation of China (Grant No. 81970663) and Natural Science Foundation of Liaoning Province (2022-MS-07), and the funding body played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.