The role of cellular senescence in metabolic diseases and the potential for senotherapeutic interventions

Huantong Zhang; Han Zhou; Xin Shen; Xingchen Lin; Yuke Zhang; Yiyi Sun; Yi Zhou; Lei Zhang; Dayong Zhang

doi:10.3389/fcell.2023.1276707

The role of cellular senescence in metabolic diseases and the potential for senotherapeutic interventions

Front Cell Dev Biol. 2023 Oct 6:11:1276707. doi: 10.3389/fcell.2023.1276707. eCollection 2023.

Authors

Huantong Zhang^#¹, Han Zhou^#¹, Xin Shen^#¹, Xingchen Lin¹, Yuke Zhang¹, Yiyi Sun¹, Yi Zhou¹, Lei Zhang^{2

3}, Dayong Zhang¹

Affiliations

¹ School of Medicine, Hangzhou City University, Hangzhou, China.
² School of Economy and Management, Zhejiang Sci-Tech University, Hangzhou, China.
³ Taizhou Hospital of Zhejiang Province, Zhejiang University, Taizhou, China.

^# Contributed equally.

Abstract

Cellular senescence represents an irreversible state of cell cycle arrest induced by various stimuli strongly associated with aging and several chronic ailments. In recent years, studies have increasingly suggested that the accumulation of senescent cells is an important contributor to the decline of organ metabolism, ultimately resulting in metabolic diseases. Conversely, the elimination of senescent cells can alleviate or postpone the onset and progression of metabolic diseases. Thus, a close relationship between senescent cells and metabolic diseases is found, and targeting senescent cells has emerged as an alternative therapy for the treatment of metabolic diseases. In this review, we summarize the role of cellular senescence in metabolic diseases, explore relevant therapeutic strategies for metabolic diseases by removing senescent cells, and provide new insights into the treatment of metabolic diseases.

Keywords: SASP; cellular senescence; diabetes mellitus; metabolic disease; senolytic.

Publication types

Review

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Basic Public Welfare Research Project of Zhejiang Province (Grant No. LGD22H250002), Scientific Research Foundation for Returned Scholars of Hangzhou City (2021), China Postdoctoral Science Foundation (2020M681811) and National College Students’ Innovative and Entrepreneurship Training Program of China (Grant Nos. 202113021030 and 202213021029).