Global impact of proteoglycan science on human diseases

Christopher Xie; Liliana Schaefer; Renato V Iozzo

doi:10.1016/j.isci.2023.108095

Global impact of proteoglycan science on human diseases

iScience. 2023 Oct 4;26(11):108095. doi: 10.1016/j.isci.2023.108095. eCollection 2023 Nov 17.

Authors

Christopher Xie¹, Liliana Schaefer², Renato V Iozzo¹

Affiliations

¹ Department of Pathology and Genomic Medicine, the Translational Cellular Oncology Program, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.
² Institute of Pharmacology and Toxicology, Goethe University, Frankfurt, Germany.

Abstract

In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological processes. The emerging roles of proteoglycans in global infections, specifically the SARS-CoV-2 pandemic, and their rising functions in regenerative medicine and biomaterial science have significantly affected our current view of proteoglycans and related compounds. The roles of proteoglycans in cancer biology and their potential use as a next-generation protein-based adjuvant therapy to combat cancer is also emerging as a constructive and potentially beneficial therapeutic strategy. We will discuss the role of proteoglycans in selected and emerging areas of proteoglycan science, such as neurodegenerative diseases, autophagy, angiogenesis, cancer, infections and their impact on mammalian diseases.

Keywords: Cancer; Cellular physiology; Neuroscience.

Publication types

Review

Abstract

Publication types

Grants and funding