The multifaceted role of extracellular ATP in sperm function: From spermatogenesis to fertilization

Heran Cao; Long Li; Shujuan Liu; Yang Wang; Xianglin Liu; Fangxia Yang; Wuzi Dong

doi:10.1016/j.theriogenology.2023.10.019

The multifaceted role of extracellular ATP in sperm function: From spermatogenesis to fertilization

Theriogenology. 2024 Jan 15:214:98-106. doi: 10.1016/j.theriogenology.2023.10.019. Epub 2023 Oct 17.

Authors

Heran Cao¹, Long Li¹, Shujuan Liu¹, Yang Wang¹, Xianglin Liu², Fangxia Yang², Wuzi Dong³

Affiliations

¹ College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
² College of Forestry, Northwest A&F University, Yangling, Shaanxi, 712100, China.
³ College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address: dongwuzi@nwsuaf.edu.cn.

PMID: 37865020
DOI: 10.1016/j.theriogenology.2023.10.019

Abstract

Extracellular adenosine 5'-triphosphate (ATP) is a vital signaling molecule involved in various physiological processes within the body. In recent years, studies have revealed its significant role in male reproduction, particularly in sperm function. This review explores the multifaceted role of extracellular ATP in sperm function, from spermatogenesis to fertilization. We discuss the impact of extracellular ATP on spermatogenesis, sperm maturation and sperm-egg fusion, highlighting the complex regulatory mechanisms and potential clinical applications in the context of male infertility. By examining the latest research, we emphasize the crucial role of extracellular ATP in sperm function and propose future research directions to further.

Keywords: Extracellular ATP; Male infertility; Sperm; Sperm function.

Publication types

Review

MeSH terms

Adenosine Triphosphate
Animals
Fertilization / physiology
Male
Semen*
Spermatogenesis / physiology
Spermatozoa* / physiology

Substances

Adenosine Triphosphate