ATR takes a crack at the nuclear envelope

Mol Cell. 2023 Oct 19;83(20):3588-3590. doi: 10.1016/j.molcel.2023.09.031.

Abstract

In this issue, Joo et al.1 and Kovacs et al.2 report that the ATR kinase promotes nuclear envelope rupture through the phosphorylation of Lamin A/C, inducing processes such as cGAS-STING pathway activation, micronuclei clearance, and potentially cell death.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins / genetics
  • Ataxia Telangiectasia Mutated Proteins / metabolism
  • Nuclear Envelope* / metabolism
  • Nucleotidyltransferases* / metabolism
  • Phosphorylation

Substances

  • Nucleotidyltransferases
  • Ataxia Telangiectasia Mutated Proteins