Viral Anterior Uveitis: A Practical and Comprehensive Review of Diagnosis and Treatment

Yun Feng; Ruby Garcia; William Rojas-Carabali; Carlos Cifuentes-González; Ikhwanuliman Putera; Jingyi Li; Rina La Distia Nora; Padmamalini Mahendradas; Vishali Gupta; Alejandra de-la-Torre; Rupesh Agrawal

doi:10.1080/09273948.2023.2271077

Viral Anterior Uveitis: A Practical and Comprehensive Review of Diagnosis and Treatment

Ocul Immunol Inflamm. 2023 Oct 20:1-15. doi: 10.1080/09273948.2023.2271077. Online ahead of print.

Authors

Yun Feng^{1

2}, Ruby Garcia³, William Rojas-Carabali^{4

5}, Carlos Cifuentes-González⁴, Ikhwanuliman Putera^{6

7

8

9}, Jingyi Li^{1

2}, Rina La Distia Nora⁶, Padmamalini Mahendradas¹⁰, Vishali Gupta¹¹, Alejandra de-la-Torre⁴, Rupesh Agrawal^{5

12

13

14

15}

Affiliations

¹ Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
² Eye Center, Peking University Third Hospital, Beijing, China.
³ Reno School of Medicine, University of Nevada, Reno, Nebraska, USA.
⁴ Neuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
⁵ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
⁶ Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Kirana Eye Hospital, Jakarta, Indonesia.
⁷ Laboratory Medical Immunology, Department of Immunology, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands.
⁸ Department of Internal Medicine, Division of Clinical Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
⁹ Department of Ophthalmology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
¹⁰ Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India.
¹¹ Advanced Eye Centre, Post- Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
¹² Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.
¹³ Moorfields Eye Hospital, NHS Foundation Trust, London, UK.
¹⁴ Singapore Eye Research Institute, The Academia, Singapore, Singapore.
¹⁵ Department of Ophthalmology and Visual Sciences, Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.

PMID: 37862684
DOI: 10.1080/09273948.2023.2271077

Abstract

Anterior uveitis is the most common type of uveitis worldwide. The etiologies of anterior uveitis can be divided into infectious and non-infectious (idiopathic, autoimmune, autoinflammatory, trauma, and others). The viral pathogens most commonly associated with infectious anterior uveitis include Herpes Simplex Virus, Varicella-Zoster Virus, Cytomegalovirus, and Rubella Virus. Other emerging causes of viral anterior uveitis are West Nile Virus, Human-Immunodeficiency Virus, Epstein-Barr Virus, Parechovirus, Dengue Virus, Chikungunya Virus, and Human Herpesvirus type 6,7, and 8. Early recognition allows prompt management and mitigates its potential ocular complications. This article provides an updated literature review of the epidemiology, clinical manifestations, diagnostic tools, and treatment options for viral anterior uveitis.

Keywords: Uveitis; anterior uveitis; diagnosis; treatment; viral uveitis.

Publication types

Review