Association between family income to poverty ratio and HPV infection status among U.S. women aged 20 years and older: a study from NHANES 2003-2016

Yuan Zhao; Jing Zhao; Ruijie Xie; Yu Zhang; Ya Xu; Jing Mao; Cheng Yan; Yi Sun

doi:10.3389/fonc.2023.1265356

Association between family income to poverty ratio and HPV infection status among U.S. women aged 20 years and older: a study from NHANES 2003-2016

Front Oncol. 2023 Oct 4:13:1265356. doi: 10.3389/fonc.2023.1265356. eCollection 2023.

Authors

Yuan Zhao¹, Jing Zhao², Ruijie Xie³, Yu Zhang⁴, Ya Xu⁴, Jing Mao¹, Cheng Yan¹, Yi Sun⁴

Affiliations

¹ Department of Clinical Laboratory, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China.
² Department of Gynecology, Hebei General Hospital, Shijiazhuang, China.
³ The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China.
⁴ Department of Clinical Laboratory, The First People's Hospital of Yunnan Province, Kunming, China.

Abstract

Background: HPV infection is closely related to the occurrence of cervical cancer and has an important adverse effect on human life and health. This study used data from the NHANES 2003-2016 to investigate the relationship between PIR and HPV infection status among Americans aged 20 and older.

Methods: The data for this cross-sectional investigation came from the 2003-2016 National Health and Nutrition Examination Survey (NHANES), which included 9580 women who were 20 years of age or older. The linear and nonlinear correlations between PIR and the presence of HPV infection were investigated using multiple linear regression and smooth curve fitting. The stability of the relationship across groups was examined using subgroup analysis and interaction tests.

Results: There were 2232 impoverished homes and 2543 rich households among the 9580 adult participants aged 20 and above. PIR (ratio of income to poverty) was found to be significantly inversely related to the presence of HPV infection [0.91 (0.89, 0.94)] after adjusting for all other covariates, and the trend persisted even after categorizing PIR into high- and low-income groups (PIR>4 and PIR<1). In addition, significant negative relationships were discovered in subgroup analyses for women aged 25 to 59 [0.90 (0.88, 0.93)], non-Hispanic whites [0.80 (0.70, 0.92)], non-diabetics [0.91 (0.88, 0.94)], and those who had ever engaged in sex [0.91 (0.89, 0.94)].

Conclusions: PIR was highly and negatively correlated with the presence of HPV infection in American women aged 20 and older. The results of this study are of great significance for preventing HPV infection and improving the accuracy of HPV screening.

Keywords: HPV; NHANES; US; association; family income to poverty ratio.

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This project was supported by the Yunnan Health Training Project of High-level Talents (grant no. L-2019023 and KH-SWR-MY-2020-005); the Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Special Project [grant no. 2019FE001 (-118)].