The role of miRNAs in Behçet's disease

Feihan Gu; Xu Huang; Wenkai Huang; Mingyu Zhao; Hu Zheng; Yuanyin Wang; Ran Chen

doi:10.3389/fimmu.2023.1249826

The role of miRNAs in Behçet's disease

Front Immunol. 2023 Oct 4:14:1249826. doi: 10.3389/fimmu.2023.1249826. eCollection 2023.

Authors

Feihan Gu¹, Xu Huang¹, Wenkai Huang¹, Mingyu Zhao¹, Hu Zheng¹, Yuanyin Wang¹, Ran Chen¹

Affiliation

¹ College and Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, China.

Abstract

The symptoms of Behçet's disease (BD), a multisystemic condition with autoimmune and inflammation as hallmarks, include arthritis, recurring oral and vaginal ulcers, skin rashes and lesions, and involvement of the nervous, gastrointestinal, and vascular systems. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), may be important regulators of inflammation and autoimmune disease. These ncRNAs are essential to the physiological and pathophysiological disease course, and miRNA in particular has received significant attention for its role and function in BD and its potential use as a diagnostic biomarker in recent years. Although promising as therapeutic targets, miRNAs must be studied further to fully comprehend how miRNAs in BD act biologically.

Keywords: Behçet’s disease; autoimmune; biomarker; miRNA; therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases*
Behcet Syndrome* / diagnosis
Behcet Syndrome* / genetics
Female
Humans
Inflammation
MicroRNAs* / genetics
RNA, Long Noncoding* / genetics

Substances

MicroRNAs
RNA, Long Noncoding

Grants and funding

This study was supported by the Research Fund of Anhui Institute of Translational Medicine (2022zhyx-C86) and the 2022 Disciplinary Construction Project in the School of Dentistry, Anhui Medical University (2022xkfyhz01).