Effect of Prebiotic Dietary Supplement Acacia senegal on Hormonal and Metabolic Markers in Polycystic Ovary Syndrome Patients: A Pilot Study

Reem I Mohamed; Ibrahim M Daoud; Awadia G Suliman; Lamis Kaddam

doi:10.7759/cureus.45480

Effect of Prebiotic Dietary Supplement Acacia senegal on Hormonal and Metabolic Markers in Polycystic Ovary Syndrome Patients: A Pilot Study

Cureus. 2023 Sep 18;15(9):e45480. doi: 10.7759/cureus.45480. eCollection 2023 Sep.

Authors

Reem I Mohamed¹, Ibrahim M Daoud², Awadia G Suliman^{3

4}, Lamis Kaddam^{5

6}

Affiliations

¹ Department of Physiology, Faculty of Medicine, Alneelain University, Khartoum, SDN.
² Department of Obstetrics and Gynaecology, Faculty of Medicine, Alneelain University, Khartoum, SDN.
³ Faculty of Radiological Sciences and Medical Imaging, Alzaiem Alazhari University, Khartoum, SDN.
⁴ Department of Diagnostic Radiology Technology, College of Applied Medical Sciences, Taibah University, Almadinah Almunawarah, SAU.
⁵ Department of Physiology, Faculty of Medicine, Alneelain University, Khartoum, Sudan, SDN.
⁶ Department of Physiology, King Abdulaziz University Faculty of Medicine, Rabigh, SAU.

Abstract

Background The most prevalent endocrine condition affecting women of reproductive age is polycystic ovarian syndrome (PCOS), which is linked to a variety of metabolic abnormalities. Although the pathogenesis of PCOS is not fully understood, it is known that oxidative stress, altered gut microbiome, and increased gonadotrophin-releasing hormone play a significant role. Gum arabic (GA) is an edible, dried, gummy exudate from the Acacia senegal tree, well-known for its prebiotic and antioxidant effects. The main objective of the study was to assess the changes in hormonal and metabolic profiles in PCOS patients after the ingestion of gum arabic. Method This was a clinical trial conducted on fifteen patients suffering from PCOS, with a mean age of 27.8 years (20-39 years). All patients experienced irregular cycles. Hormonal and metabolic markers (follicular stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), fasting insulin, total cholesterol (TC), and glycosylated hemoglobin (HBA1c) were measured before and after the ingestion of gum arabic (30 g/day of GA dissolved in 250 ml water for eight weeks) on the second day of the menstrual cycle after granting ethical approval from the National Medicine and Poisons Board and from the participants of the study. Results The study demonstrated a significant decrease in the luteinizing hormone level, FSH/LH ratio, and cholesterol pre- and post-gum arabic ingestion (p-values 0.001, 0.013, and 0.007, respectively). Follicular stimulating hormone slightly reduced post-ingestion with no significant difference (p-value 0.414). No significant changes were seen in the testosterone, insulin, or HBA1c levels. Conclusion The study concluded that gum arabic ingestion for eight weeks decreases the luteinizing hormone and LH/FSH ratio and improves the metabolic profile by reducing the cholesterol level in PCOS patients.

Keywords: cholesterol; fsh; gum arabic (ga); hormonal profiles; insulin; lh; lh/fsh ratio; metabolic markers; polycystic ovary syndrome (pcos); testosteron.