SWADESH: a multimodal multi-disease brain imaging and neuropsychological database and data analytics platform

Pravat K Mandal; Komal Jindal; Saurav Roy; Yashika Arora; Shallu Sharma; Shallu Joon; Anshika Goel; Zoheb Ahasan; Joseph C Maroon; Kuldeep Singh; Kanika Sandal; Manjari Tripathi; Pooja Sharma; Avantika Samkaria; Shradha Gaur; Sandhya Shandilya

doi:10.3389/fneur.2023.1258116

SWADESH: a multimodal multi-disease brain imaging and neuropsychological database and data analytics platform

Front Neurol. 2023 Oct 4:14:1258116. doi: 10.3389/fneur.2023.1258116. eCollection 2023.

Authors

Pravat K Mandal^{1

2}, Komal Jindal¹, Saurav Roy¹, Yashika Arora¹, Shallu Sharma¹, Shallu Joon¹, Anshika Goel¹, Zoheb Ahasan¹, Joseph C Maroon³, Kuldeep Singh¹, Kanika Sandal¹, Manjari Tripathi⁴, Pooja Sharma⁵, Avantika Samkaria¹, Shradha Gaur¹, Sandhya Shandilya¹

Affiliations

¹ Neuroimaging and Neurospectroscopy (NINS) Laboratory, National Brain Research Centre, Gurgaon, India.
² Florey Institute of Neuroscience and Mental Health, Melbourne School of Medicine Campus, Melbourne, VIC, Australia.
³ Department of Neurosurgery, University of Pittsburgh Medical School, Pittsburgh, PA, United States.
⁴ Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
⁵ Medanta Institute of Education and Research, Medanta-The Medicity Hospital, Gurgaon, India.

Abstract

Multimodal neuroimaging data of various brain disorders provides valuable information to understand brain function in health and disease. Various neuroimaging-based databases have been developed that mainly consist of volumetric magnetic resonance imaging (MRI) data. We present the comprehensive web-based neuroimaging platform "SWADESH" for hosting multi-disease, multimodal neuroimaging, and neuropsychological data along with analytical pipelines. This novel initiative includes neurochemical and magnetic susceptibility data for healthy and diseased conditions, acquired using MR spectroscopy (MRS) and quantitative susceptibility mapping (QSM) respectively. The SWADESH architecture also provides a neuroimaging database which includes MRI, MRS, functional MRI (fMRI), diffusion weighted imaging (DWI), QSM, neuropsychological data and associated data analysis pipelines. Our final objective is to provide a master database of major brain disease states (neurodegenerative, neuropsychiatric, neurodevelopmental, and others) and to identify characteristic features and biomarkers associated with such disorders.

Keywords: Alzheimer’s; KALPANA; MR spectroscopy; Parkinson’s; data analytics; database; glutathione; iron.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. PM (Principal Investigator) thanks various agencies for their partial financial support, namely Tata Innovation Fellowship (Department of Biotechnology, Ministry of Science and Technology, Government of India; award no. BT/HRD/01/05/2015), Indo–Australian grant strategic funding to PM (grant no. BT/Indo-Aus/10/31/2016), and the Ministry of Electronics and Information Technology (grant no 4(5)/2019-ITEA).