Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome

Elisabeth Naschberger; Maximilian Fuchs; Nicholas Dickel; Meik Kunz; Bernt Popp; Charles Gwellem Anchang; Richard Demmler; Yanmin Lyu; Steffen Uebe; Arif Bülent Ekici; Carol Immanuel Geppert; Arndt Hartmann; Christian Flierl; Katja Petter; Tobias Gass; Simon Völkl; Michael Scharl; Andreas Ramming; Claudia Günther; Susanne Merkel; Vera Simone Schellerer; Michael Stürzl

doi:10.1002/cac2.12489

Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome

Cancer Commun (Lond). 2023 Nov;43(11):1280-1285. doi: 10.1002/cac2.12489. Epub 2023 Oct 19.

Authors

Elisabeth Naschberger^{1

2}, Maximilian Fuchs^{3

4}, Nicholas Dickel³, Meik Kunz^{3

4}, Bernt Popp⁵, Charles Gwellem Anchang⁶, Richard Demmler^{1

2}, Yanmin Lyu^{1

2}, Steffen Uebe⁵, Arif Bülent Ekici⁵, Carol Immanuel Geppert^{2

7}, Arndt Hartmann^{2

7}, Christian Flierl¹, Katja Petter¹, Tobias Gass¹, Simon Völkl⁸, Michael Scharl⁹, Andreas Ramming⁶, Claudia Günther¹⁰, Susanne Merkel^{2

11}, Vera Simone Schellerer^{2

11}, Michael Stürzl^{1

2}

Affiliations

¹ Division of Molecular and Experimental Surgery, Translational Research Center, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Bavaria, Germany.
² Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN), Erlangen, Bavaria, Germany.
³ Chair of Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Bavaria, Germany.
⁴ Fraunhofer Institute of Toxicology and Experimental Medicine, Lower saxony, Hannover, Germany.
⁵ Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Bavaria, Germany.
⁶ Department of Medicine 3, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Bavaria, Germany.
⁷ Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Bavaria, Germany.
⁸ Department of Internal Medicine 5 - Hematology and Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Bavaria, Germany.
⁹ Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Canton Zurich, Zurich, Switzerland.
¹⁰ Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Bavaria, Germany.
¹¹ Department of Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Bavaria, Germany.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Colonic Neoplasms* / genetics
DNA Methylation
Epigenesis, Genetic
Humans
Tumor Microenvironment* / genetics