Although underwater wireless optical communication (UWOC) receives much interest lately, security issues associated with it get little attention. In this work, it is the first attempt to investigate the physical layer security (PLS) performance of the vertical UWOC system with perfect and imperfect channel state information (CSI). Specifically speaking, the communication between two legitimate peers in the presence of an external eavesdropper is studied from the information-theoretic security perspective. Assuming that turbulence-induced fading over the vertical UWOC links is respectively subject to cascaded lognormal (LN) and Gamma-Gamma (GG) distributions for weak and moderate/strong turbulence conditions, and the angular pointing error is randomized by the Beckmann distribution, the composite cascaded statistical fading models are derived with the comprehensive effects of path loss, underwater turbulence, angular pointing errors, and channel estimation error. On the basis of these models, analysis frameworks of the probability of strictly positive secrecy capacity (SPSC), secrecy outage probability (SOP), and average secrecy capacity (ASC) are further obtained for this UWOC system, which are confirmed by Monte Carlo (MC) simulations. Furthermore, the effects including the number of layers, the level of channel estimation error, the link distance, the location of the eavesdropper, the quality of the main and eavesdropping channels on this system are analyzed for different water conditions. The presented results give valuable insights into the practical aspects of deployment of UWOC networks.