Force opens a monomeric channel pore

Wenjun Guo; Lei Chen

doi:10.1016/j.neuron.2023.08.029

Force opens a monomeric channel pore

Neuron. 2023 Oct 18;111(20):3135-3137. doi: 10.1016/j.neuron.2023.08.029.

Authors

Wenjun Guo¹, Lei Chen²

Affiliations

¹ State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China.
² State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; National Biomedical Imaging Center, Peking University, Beijing, 100871, China. Electronic address: chenlei2016@pku.edu.cn.

PMID: 37857087
DOI: 10.1016/j.neuron.2023.08.029

Abstract

In this issue of Neuron, Zheng et al.¹ report the monomeric architecture of mechanosensitive ion channels TMEM63A and TMEM63B. They show that these high-threshold channels function as monomers on the plasma membrane.

Publication types

Comment

MeSH terms

Cell Membrane / metabolism
Ion Channels* / metabolism
Mechanotransduction, Cellular* / physiology
Neurons / metabolism

Substances

Ion Channels