The Possible Association of IL-6R Gene Polymorphisms in the Development of Diabetic Nephropathy

Ebrahim Ebrat; Seyyedeh Mina Hejazian; Elham Ahmadian; Sepideh Zununi Vahed; Majid Mobasseri; Mohammadreza Ardalan

doi:10.2174/0115733998245369231009111221

The Possible Association of IL-6R Gene Polymorphisms in the Development of Diabetic Nephropathy

Curr Diabetes Rev. 2023 Oct 17. doi: 10.2174/0115733998245369231009111221. Online ahead of print.

Authors

Ebrahim Ebrat¹, Seyyedeh Mina Hejazian¹, Elham Ahmadian¹, Sepideh Zununi Vahed¹, Majid Mobasseri², Mohammadreza Ardalan¹

Affiliations

¹ Tabriz University of Medical Sciences Kidney Research Center Tabriz Iran.
² Tabriz University of Medical Sciences Endocrine Research Center Tabriz Iran.

PMID: 37855360
DOI: 10.2174/0115733998245369231009111221

Abstract

Background: Diabetic nephropathy (DN) is a common complication of type 2 diabetes (T2D). Chronic inflammation and a combination of environmental and genetic factors are involved in the pathogenesis and development of DN.

Objective: This case-control study aimed to determine the relationship between rs7529229 and rs2228145 polymorphisms of the IL-6R gene with the incidence of nephropathy among T2D patients.

Methods: Fifty-six diabetic patients with nephropathy and 57 T2D patients without nephropathy were included based on inclusion criteria, along with 150 healthy individuals.

Results: The frequencies of AC and CC genotype distributions of the rs2228145 polymorphism in DN patients were significantly higher than in healthy individuals (24.1 and 9.3% versus 10.7 and 6.7%, respectively, P= 0.02). Moreover, the frequency of allele C was higher in DN patients compared to healthy controls (21.30% versus 12%, P=0.025). However, genotype distribution and allele frequencies of the rs7529229 IL-6R polymorphism in DN patients were not statistically significant in comparison with diabetic patients and healthy individuals (P> 0.05).

Conclusion: The results showed that the allele and genotype distribution frequencies of rs2228145 IL-6R gene polymorphism in patients with DN were significantly higher than in healthy individuals. Therefore, the presence of this polymorphism may be involved in the development of diabetic nephropathy in this population.

Keywords: Diabetic nephropathy (DN); Gene polymorphism; IL-6R gene; Type 2 diabetes (T2D); cytokine.