Therapeutic mechanisms of ginseng in coronary heart disease

Miao-Miao Tang; Shu-Ting Zhao; Ran-Qi Li; Wei Hou

doi:10.3389/fphar.2023.1271029

Therapeutic mechanisms of ginseng in coronary heart disease

Front Pharmacol. 2023 Oct 3:14:1271029. doi: 10.3389/fphar.2023.1271029. eCollection 2023.

Authors

Miao-Miao Tang¹, Shu-Ting Zhao¹, Ran-Qi Li¹, Wei Hou¹

Affiliation

¹ Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China.

Abstract

Coronary heart disease (CHD) is the most common clinical manifestation of cardiovascular disease. It is characterized by myocardial ischemia, which is caused by coronary atherosclerosis. CHD is a significant global health problem with increasing prevalence every year because of significant changes in the lifestyles and diets. Ginseng is a traditional Chinese medicinal herb that has been used in food preparations and traditional medicine for several centuries. Several studies have demonstrated that ginseng improved cardiac function by normalizing blood glucose levels and decreasing blood pressure, oxidative stress, platelet aggregation, and lipid dysregulation in vivo. This review describes the current understanding of the mechanisms by which ginseng alleviates CHD, and provides a reference for the clinical development and application of ginseng as an alternative therapy for CHD.

Keywords: antioxidation; atherosclerosis; blood pressure; coronary heart disease (CHD); ginseng; heart; lipid; platelets.

Publication types

Review

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by funds from the Natural Science Foundation of Jilin Province (Grant No. YDZJ202201ZYTS190) and Central Public interest Scientific Institution Basal Research Fund (Grant No. 1610342023011).