Physicochemical parameters and modes of interaction associated with the micelle formation of a mixture of tetradecyltrimethylammonium bromide and cefixime trihydrate: effects of hydrotropes and temperature

Md Al Amin Hossain; Tamanna Islam; Javed Masood Khan; Md Tuhinur R Joy; Shamim Mahbub; Salman A Khan; Anis Ahmad; Mohammad Majibur Rahman; Md Anamul Hoque; Shariff E Kabir

doi:10.1039/d3ra04748b

Physicochemical parameters and modes of interaction associated with the micelle formation of a mixture of tetradecyltrimethylammonium bromide and cefixime trihydrate: effects of hydrotropes and temperature

RSC Adv. 2023 Oct 17;13(43):30429-30442. doi: 10.1039/d3ra04748b. eCollection 2023 Oct 11.

Authors

Affiliations

¹ Department of Chemistry, Jashore University of Science and Technology Jashore 7408 Bangladesh joytuhinur@yahoo.com.
² Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University Riyadh 11451 Saudi Arabia.
³ Nuclear Safety, Security & Safeguards Division, Bangladesh Atomic Energy Regulatory Authority Agargaon Dhaka 1207 Bangladesh.
⁴ Physical Sciences Section (Chemistry), School of Sciences, Maulana Azad National Urdu University Hyderabad 500032 Telangana India.
⁵ Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine Miami FL USA.
⁶ Department of Environmental Sciences, Jahangirnagar University Savar Dhaka 1342 Bangladesh.
⁷ Department of Chemistry, Jahangirnagar University Savar Dhaka 1342 Bangladesh ahoque_ju@juniv.edu.
⁸ Department of Chemistry, Jagannath University Dhaka 1100 Bangladesh.

Abstract

The interaction between an antibiotic drug (cefixime trihydrate (CMT)) and a cationic surfactant (tetradecyltrimethylammonium bromide (TTAB)) was examined in the presence of both ionic and non-ionic hydrotropes (HTs) over the temperature range of 300.55 to 320.55 K. The values of the critical micelle concentration (CMC) of the TTAB + CMT mixture were experienced to have dwindled with an enhancement of the concentrations of resorcinol (ReSC), sodium benzoate (NaBz), sodium salicylate (NaS), while for the same system, a monotonically augmentation of CMC was observed in aq. 4-aminobenzoic acid (PABA) solution. A gradual increase in CMC, as a function of temperature, was also observed. The values of the degree of counterion binding (β) for the TTAB + CMT mixture were experienced to be influenced by the concentrations of ReSC/NaBz/NaS/PABA and a change in temperature. The micellization process of TTAB + CMT was observed to be spontaneous (negative standard Gibbs free energy change (ΔG⁰_m)) at all conditions studied. Also, the values of standard enthalpy change (ΔH⁰_m) and entropy change (ΔS⁰_m) were found negative and positive, respectively (with a few exceptions), for the test cases indicating an exothermic and enthalpy-entropy directed micellization process. The recommended interaction forces between the components in the micellar system are electrostatic and hydrophobic interactions. In this study, the values of ΔC⁰_m were negative in aqueous NaBz, ReSC, and PABA media, and positive in case of NaS. An excellent compensation scenario between the enthalpy and entropy for the CMT + TTAB mixed system in the investigated HTs solutions is well defined in the current work.