Clinical, genomic, and epigenomic analyses of H3K27M-mutant diffuse midline glioma long-term survivors reveal a distinct group of tumors with MAPK pathway alterations

Affiliations

• ¹ Department of Pediatrics, Michigan Medicine, Ann Arbor, MI, USA.
• ² Department of Neurology-2, Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
• ³ Onconeurotek, AP-HP, Hôpital Pitié-Salpêtrière, 75013, Paris, France.
• ⁴ Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Épinière, ICM, Paris, France.
• ⁵ Department of Neurology, NYU Langone Health, New York, NY, USA.
• ⁶ Department of Pathology, NYU Langone Health, New York, NY, USA.
• ⁷ Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.
• ⁸ Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
• ⁹ Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
• ¹⁰ Department of Neurosurgical Oncology and Vascular Neurosurgery, Pierre Wertheimer Neurological and Neurosurgical Hospital, Hospices Civils de Lyon, Université Lyon 1, CRCL, UMR Inserm 1052, CNRS 5286, 69008, Lyon, France.
• ¹¹ Neuro-Oncology Department, Hospices Civils de Lyon, Université Lyon 1, CRCL, UMR Inserm 1052, CNRS 5286, 69000, Lyon, France.
• ¹² Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
• ¹³ Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
• ¹⁴ Department of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan.
• ¹⁵ Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
• ¹⁶ Department of Pediatric Hematology, Oncology, Immunology and Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.
• ¹⁷ Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ) and German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
• ¹⁸ Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
• ¹⁹ Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
• ²⁰ Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
• ²¹ Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
• ²² Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA.
• ²³ Department of Urology, University of Michigan, Ann Arbor, MI, USA.
• ²⁴ Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
• ²⁵ Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
• ²⁶ Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
• ²⁷ Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.
• ²⁸ Laboratory of Computational Neuro-Oncology, School of Life Sciences, Swiss Institute for Experimental Cancer Research, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland. sebastian.waszak@epfl.ch.
• ²⁹ Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. sebastian.waszak@epfl.ch.
• ³⁰ EPFL SV ISREC UPWASZAK, AAB 238 (Batiment AAB), Station 19, 1015, Lausanne, Switzerland. sebastian.waszak@epfl.ch.
• ³¹ Department of Pediatrics, Michigan Medicine, Ann Arbor, MI, USA. ckoschma@med.umich.edu.
• ³² University of Michigan, 3520D MSRB I, 1150 W Medical Center Dr, Ann Arbor, MI, 48109, USA. ckoschma@med.umich.edu.