Miliarial-type gout in association with chronic use of glucocorticoids

Rheumatol Int. 2024 Mar;44(3):543-547. doi: 10.1007/s00296-023-05486-0. Epub 2023 Oct 18.

Abstract

A 59-year-old male patient with long-standing tophaceous gout (more than 30 years) characterized by polyarticular involvement and recurrent disseminated tophi formation; his past medical history is relevant for poor adherence to urate-lowering medications, as well as persistent use of self-prescribed systemic glucocorticoids. Despite achieving therapeutic goals for serum uric acid levels, new tophi formation with an intradermal location in the form of "miliarial-type gout" was documented. Due to functional limitations, the patient underwent surgical resection of the olecranon bursa. This case illustrates a widespread and recurrent tophi formation associated with long-standing gout and regular and sustained glucocorticoid use, despite an adequate disease control based on serum urate levels and involving an intradermal location of tophi presenting as "miliarial-type" lesions. In addition, the coexistence of urate and cholesterol crystal deposition disease in olecranon gouty bursitis is presented. Finally, a sonographic extended field of view of lesions distributed along the patient's extremities is presented as a novel characterization of this condition.

Keywords: Cholesterol crystals; Glucocorticoids; Intradermal tophi; Miliarial gout; Ultrasound.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Arthritis, Gouty*
  • Glucocorticoids / therapeutic use
  • Gout* / complications
  • Gout* / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Uric Acid

Substances

  • Uric Acid
  • Glucocorticoids