Bisabolane-type sesquiterpenoids and bacillibactin from the marine-derived fungus Aspergillus sydowii SCSIO 41041 and their enzyme inhibiting activity

Ying-Ying Song; Qing-Xia Liu; Xiao-Yan Pang; Zhi-Yun Chen; Hong-Hui Huang; Jun-Feng Wang; Yong-Hong Liu

doi:10.1080/14786419.2023.2269470

Bisabolane-type sesquiterpenoids and bacillibactin from the marine-derived fungus Aspergillus sydowii SCSIO 41041 and their enzyme inhibiting activity

Nat Prod Res. 2023 Oct 18:1-4. doi: 10.1080/14786419.2023.2269470. Online ahead of print.

Authors

Ying-Ying Song^{1

2}, Qing-Xia Liu³, Xiao-Yan Pang¹, Zhi-Yun Chen^{1

2}, Hong-Hui Huang³, Jun-Feng Wang^{1

2

4}, Yong-Hong Liu^{1

2

4}

Affiliations

¹ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ Guangdong Provincial Key Laboratory of Fishery Ecology and Environment, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China.
⁴ Sanya Institute of Oceanology Eco-Environmental Engineering, Yazhou Scientific Bay, Sanya, China.

PMID: 37850461
DOI: 10.1080/14786419.2023.2269470

Abstract

Twelve compounds, including eleven bisabolane-type sesquiterpenoids (1 - 11), and one bacillibactin (12) were identified from marine-derived fungus Aspergillus sydowii SCSIO 41041 isolated from Creseis acicula. The chemical structures were elucidated by the basis of spectroscopic evidences, including HRESIMS, NMR and optical rotation. Biologically, all compounds were evaluated for their acetyl cholin-esterase (AChE) enzyme, pancreatic lipase (PL) enzyme, neuraminidase (NA) and phosphodiesterase 4 (PDE4) inhibitory activities. Compound 12 displayed significant inhibitory activity against neuraminidase (NA) with an IC₅₀ value of 24.0 μM, which was equivalent to the positive drug oseltamivir phosphate (IC₅₀ value of 20.0 μM). And the NA inhibitory activity was confirmed by molecular docking analysis.

Keywords: Aspergillus sydowii; Creseis acicula; anti-neuraminidase activity.