Reductive coupling of nitroarenes with carboxylic acids - a direct route to amide synthesis

Org Biomol Chem. 2023 Nov 1;21(42):8477-8481. doi: 10.1039/d3ob01452e.

Abstract

A straightforward and selective way for the preparation of amides from nitroarenes and carboxylic acids using carbon monoxide as a reductant was developed. This protocol does not require any non-gaseous additives, thus simplifying product isolation. Aliphatic carboxylic acid was modified in the presence of aromatic ones, and reducible functional groups such as CC, Ar-Br, and R-NO2 were saved.