Recent advances on cyclodepsipeptides: biologically active compounds for drug research

Si-Xuan Liu; Si-Yi Ou-Yang; Yong-Fu Lu; Chun-Lin Guo; Si-Yang Dai; Chang Li; Tian-Yi Yu; Yue-Hu Pei

doi:10.3389/fmicb.2023.1276928

Recent advances on cyclodepsipeptides: biologically active compounds for drug research

Front Microbiol. 2023 Oct 2:14:1276928. doi: 10.3389/fmicb.2023.1276928. eCollection 2023.

Authors

Si-Xuan Liu¹, Si-Yi Ou-Yang¹, Yong-Fu Lu¹, Chun-Lin Guo¹, Si-Yang Dai¹, Chang Li^{1

2}, Tian-Yi Yu³, Yue-Hu Pei¹

Affiliations

¹ Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China.
² Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province, College of Pharmacy, Harbin Medical University, Harbin, China.
³ The Third Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.

Abstract

Cyclodepsipeptides are a large family of peptide-related natural products consisting of hydroxy and amino acids linked by amide and ester bonds. A number of cyclodepsipeptides have been isolated and characterized from fungi and bacteria. Most of them showed antitumor, antifungal, antiviral, antimalarial, and antitrypanosomal properties. Herein, this review summarizes the recent literatures (2010-2022) on the progress of cyclodepsipeptides from fungi and bacteria except for those of marine origin, in order to enrich our knowledge about their structural features and biological sources.

Keywords: antimicrobial; bacteria; biological activity; cyclodepsipeptide; fungi.

Publication types

Review