Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures

Front Immunol. 2023 Oct 2:14:1264325. doi: 10.3389/fimmu.2023.1264325. eCollection 2023.

Abstract

Thymic epithelial tumors (TETs) are a rare and diverse group of neoplasms characterized by distinct molecular signatures. This review delves into the complex molecular networks of TETs, highlighting key aspects such as chromosomal abnormalities, molecular subtypes, aberrant gene mutations and expressions, structural gene rearrangements, and epigenetic changes. Additionally, the influence of the dynamic tumor microenvironment on TET behavior and therapeutic responses is examined. A thorough understanding of these facets elucidates TET pathogenesis, offering avenues for enhancing diagnostic accuracy, refining prognostic assessments, and tailoring targeted therapeutic strategies. Our review underscores the importance of deciphering TETs' unique molecular signatures to advance personalized treatment paradigms and improve patient outcomes. We also discuss future research directions and anticipated challenges in this intriguing field.

Keywords: cellular signaling network; genomic; molecular; thymic carcinoma; thymic epithelial tumors; thymoma.

Publication types

  • Review

MeSH terms

  • Humans
  • Neoplasms, Glandular and Epithelial* / diagnosis
  • Neoplasms, Glandular and Epithelial* / genetics
  • Prognosis
  • Thymoma* / genetics
  • Thymus Neoplasms* / diagnosis
  • Thymus Neoplasms* / genetics
  • Thymus Neoplasms* / pathology
  • Tumor Microenvironment / genetics

Supplementary concepts

  • Thymic epithelial tumor

Grants and funding

The authors declare no financial support was received for the research, authorship, and/or publication of this article.