A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures

Richard J Kuhn; Alan D T Barrett; Aravinda M Desilva; Eva Harris; Laura D Kramer; Ruth R Montgomery; Theodore C Pierson; Alessandro Sette; Michael S Diamond

doi:10.1093/infdis/jiad193

A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures

J Infect Dis. 2023 Oct 18;228(Suppl 6):S398-S413. doi: 10.1093/infdis/jiad193.

Authors

Richard J Kuhn^{1

2}, Alan D T Barrett^{3

4}, Aravinda M Desilva⁵, Eva Harris⁶, Laura D Kramer⁷, Ruth R Montgomery⁸, Theodore C Pierson⁹, Alessandro Sette^{10

11}, Michael S Diamond^{12

13}

Affiliations

¹ Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
² Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, Indiana, USA.
³ Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
⁴ Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, Texas, USA.
⁵ Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
⁶ Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California, USA.
⁷ School of Public Health, State University of New York at Albany, Albany, New York, USA.
⁸ Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
⁹ Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
¹⁰ Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, California, USA.
¹¹ Department of Medicine, University of California in San Diego, San Diego, California, USA.
¹² Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.
¹³ Department of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA.

PMID: 37849402
PMCID: PMC10582523 (available on 2024-10-18)
DOI: 10.1093/infdis/jiad193

Abstract

Flaviviruses are a genus within the Flaviviridae family of positive-strand RNA viruses and are transmitted principally through mosquito and tick vectors. These viruses are responsible for hundreds of millions of human infections worldwide per year that result in a range of illnesses from self-limiting febrile syndromes to severe neurotropic and viscerotropic diseases and, in some cases, death. A vaccine against the prototype flavivirus, yellow fever virus, has been deployed for 85 years and is highly effective. While vaccines against some medically important flaviviruses are available, others have proven challenging to develop. The emergence and spread of flaviviruses, including dengue virus and Zika virus, demonstrate their pandemic potential. This review highlights the gaps in knowledge that need to be addressed to allow for the rapid development of vaccines against emerging flaviviruses in the future.

Keywords: antibody neutralization; antibody-dependent enhancement; arbovirus; dynamics; flavivirus; interferon; vaccine; virus-host interaction.

Publication types

Review
Research Support, N.I.H., Intramural

MeSH terms

Animals
Flavivirus Infections* / prevention & control
Flavivirus*
Humans
Mosquito Vectors
Vaccines*
Zika Virus Infection* / prevention & control
Zika Virus*

Substances

Vaccines