Association of Toll-like receptor 4 gene polymorphism with multiple sclerosis in Iranian patients

Abdolreza Sotoodeh Jahromi; Saiedeh Erfanian; Sobhan Safavi; Abazar Roustazadeh

Association of Toll-like receptor 4 gene polymorphism with multiple sclerosis in Iranian patients

Acta Neurol Taiwan. 2024 Mar 30:33(1):1-6.

Authors

Abdolreza Sotoodeh Jahromi¹, Saiedeh Erfanian², Sobhan Safavi³, Abazar Roustazadeh²

Affiliations

¹ Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran; Medical Immunology Department, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
² Department of Biochemistry, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran; Department of Advanced Medical Sciences and Technologies, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.
³ Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.

PMID: 37849336

Abstract

Multiple sclerosis is a chronic debilitating disease with unknown pathogenesis. Recent studies indicated that pathogen recognition receptors such as Toll-like receptor 4 may have a role in pathogenesis of MS. The aim of the study was to evaluate the association of rs1927911 polymorphism in TLR4 gene with MS.

Keywords: Gene variation; Multiple sclerosis Toll-like receptor..

MeSH terms

Genetic Predisposition to Disease
Humans
Iran
Multiple Sclerosis* / genetics
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Toll-Like Receptor 4* / genetics

Substances

Toll-Like Receptor 4
TLR4 protein, human