Primary splenic multicystic peritoneal mesothelioma in a young healthy male

Matthew D Price; Shuait Nair; James Harris

doi:10.1093/jscr/rjad551

Primary splenic multicystic peritoneal mesothelioma in a young healthy male

J Surg Case Rep. 2023 Oct 14;2023(10):rjad551. doi: 10.1093/jscr/rjad551. eCollection 2023 Oct.

Authors

Matthew D Price¹, Shuait Nair², James Harris^{1

3}

Affiliations

¹ Department of Surgery, Johns Hopkins School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, United States.
² The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
³ Department of Surgery, The Johns Hopkins Howard County General Hospital, Howard County, MD 21044, United States.

Abstract

Multicystic peritoneal mesothelioma (BMPM) is a rare, usually benign tumor that arises from peritoneal mesothelial cells that most commonly occurs in women of reproductive age. Pathogenesis of these tumors is thought to come from chronic inflammation from prior surgery, endometriosis, trauma, or recurrent peritonitis. Here we report a case of primary splenic BMPM in a 20-year-old male with no past medical or surgical history and without any typical risk factors for this condition. He underwent an open splenectomy without complication. Pathology revealed an 18 × 4 × 11 cm³ spleen with a cyst occupying 75% of the splenic surface. Sections revealed a multilocular cyst with trabeculated walls and immunohistochemical staining positive for cytokeratin (AE1/AE3) consistent with BMPM. One year post operatively he remains asymptomatic; however, his interval computed tomography (CT) scan revealed several sub centimeter nodules that either represents small splenules or neoplastic implants. These will be followed with close interval imaging.

Keywords: benign multicystic peritoneal mesothelioma; cytokeratin; spleen; splenic.

Publication types

Case Reports

Grants and funding

T32 CA126607/CA/NCI NIH HHS/United States